October 7, 2021

Abstracts FDIME Grant winners

Moulis (France, 2017): The prevalence of thrombocytopenia (too few platelets) and thrombocytosis (too many platelets) and the association with hospital admission and mortality. Platelets are involved in clot formation. However, they have multiple effects. Notably, they are involved in immune system regulation, participating in the control of infections, and may complicate auto-immune diseases and cancers. Abnormal platelet count (thrombocytopenia and thrombocytosis) reflect disease severity in many condition and therefore can be used as a biomarker of disease severity in patients acutely admitted to hospital for medical conditions. Arvaniti (Greece, 2018): Epigenetics (changes in genes expression) in autoimmune liver diseases (ALDs) In our research we studied complex chemical processes and genetic (DNA) changes in blood cells (B and T lymphocytes) in patients with autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). A relationship between changes in these chemical processes with disease activity was found, probably explaining part of the pathogenesis of the diseases and opening new ways for treatment strategies. Lanzillotta (Italy, 2020): Towards treatment optimization in autoimmune pancreatitis (AIP). Autoimmune pancreatitis (AIP) is a rare form of inflammation of the pancreas. It carries a higher risk for metabolic and infectious complications, related to glycaemic derangements and biliary strictures or immunosuppressive […]